Randomized Controlled Trial of Intensive Versus Conservative Glucose Control in Patients Undergoing Coronary Artery Bypass Graft Surgery: GLUCO-CABG Trial

摘要: OBJECTIVE The optimal level of glycemic control needed to improve outcomes in cardiac surgery patients remains controversial. RESEARCH DESIGN AND METHODS We randomized with diabetes ( n = 152) and without hyperglycemia 150) an intensive glucose target 100–140 mg/dL 151) or a conservative 141–180 after coronary artery bypass (CABG) surgery. After the care unit (ICU), received single treatment regimen hospital 90 days postdischarge. Primary outcome was differences composite complications, including mortality, wound infection, pneumonia, bacteremia, respiratory failure, acute kidney injury, major cardiovascular events. RESULTS Mean ICU 132 ± 14 (interquartile range [IQR] 124–139) 154 17 (IQR 142–164) group P < 0.001). There were no significant complications between groups (42 vs. 52%, 0.08). observed heterogeneity effect according status, among treated regimens (49 48%, 0.87), but lower rate compared (34 55%, 0.008). CONCLUSIONS Intensive insulin therapy 100 140 did not significantly reduce perioperative 141 180 CABG Subgroup analysis showed number diabetes, regimen. Large prospective studies are confirm these findings.