UV activation of mammalian stress protiens

摘要: Ultraviolet radiation may be divided into the non-solar UVC region, solar UVB (290–320 nm) region which is strongly absorbed by nucleic acids, and UVA (320–380 less acids proteins but causes a variety of oxidative events. As consequence these different properties, UVC/UVB radiations induce an array stress quite distinct from those induced radiations. Although many studies with involve lethal doses, it clear that have property mimicking growth factor responses stimulate various signal transduction pathways lead to gene activation including transcriptional jun fos proto-oncogenes. Furthermore, irradiation skin, at physiologically relevant doses can increase levels ornithine decarboxylase, cytokines, p53 tumor suppressor protein limited extent, nuclear oncogene products. Non-cytoxic exposures up-regulation several genes collagenase, heme oxygenase 1, specific phosphatase (CL100) phospholipases. At least for there evidence alteration involved in pathway defense against stress. However, much information lacking quest build up complete picture physiological pathological significance UV inducible reported.