A generalized health economic and outcomes research model for the evaluation of companion diagnostics and targeted therapies

摘要: Aims: To present a generalized model to evaluate health and economic outcomes of targeted drug therapies associated companion diagnostic tests with two applications. Method: An analytical derivatives applied nonlinear equation representing the costs benefits therapy diagnostics is developed. Economic analysis then breast colorectal cancer application multiparameter sensitivity analysis. Results: The readily facilitates trade-off between, for example, alternative test strategy cost performance, accounts benefits. Example applications demonstrate performance are generally more critical parameters relative cost. Conclusion: While obtaining accurate data on benefits, remains key challenge in these analyses, presents trade-offs priorities ...