Embryonic ‘binge’ cocaine exposure alters neural-immune and neural-endocrine interactions in young chickens: involvement of serotonin2 receptors

摘要: Abstract As part of our characterization the developmental consequences prenatal cocaine exposure, was injected into eggs containing viable chicken embryos on embryonic day (E) 18 and fever response to endotoxin lipopolysaccharide (LPS) a delayed-type hypersensitivity phytohemagglutinin (PHA) were assessed postnatally. E18 exposure did not affect basal body temperature. LPS induced in chicks at 4 h post-injection post-hatch (D) 2 D24. suppressed peak LPS-induced by 50% both ages. also reaction an intradermal injection PHA D17, while having no effect saline injection. To determine importance serotonin2 (5-HT2) receptors toxicity cocaine, varying doses 5-HT2 antagonist ritanserin E17 followed E18. Ritanserin, like alter temperature, but it dose-relatedly attenuated or blocked cocaine’s D4 Ritanserin pretreatment able block blunted isolation stress seen D16 following exposure. Thus, late significantly alters adaptive responses, played mediating role effect.