Combination antiretroviral therapy for HIV infection

摘要: The primary goal of antiretroviral therapy for human immunodeficiency virus (HIV) infection is suppression viral replication. Evidence indicates that the optimal way to achieve this by initiating combination with two or more agents. agents now licensed in United States use include five nucleoside analog reverse transcriptase inhibitors (zidovudine, didanosine, zalcitabine, stavudine and lamivudine), nonnucleoside (delavirdine nevirapine) four protease (saquinavir, ritonavir, indinavir nelfinavir). Current recommendations suggest be considered any patient a load higher than 5,000 20,000 copies per mL, regardless CD4+ count. Selection regimen must take into account patient's prior history use, side effects these drug-drug interactions occur among other drugs as well. Because potential resistance, should only used therapy. Antiretroviral are rapidly being developed approved, so physicians make increasingly complex treatment decisions about medications which they may unfamiliar.