Does Poorer Pulmonary Function Accelerate Arterial Stiffening?: A Cohort Study With Repeated Measurements of Carotid-Femoral Pulse Wave Velocity.

摘要: Whether poorer pulmonary function accelerates progression of arterial stiffness remains unknown as prior observational studies have not examined longitudinal changes in relation to earlier function. Data (N=5342, 26% female) were drawn from the Whitehall II cohort study. Participants completed repeated assessments forced expiratory volume 1 second (FEV1, L) and carotid-femoral pulse wave velocity (cf-PWV, m/s) over 5 years. The effect FEV1 on later cf-PWV its was estimated using linear mixed-effects modeling. Possible explanatory mechanisms, such mediation by low-grade systemic inflammation, common-cause explanation preexisting cardiometabolic risk factors, reverse-causation bias, assessed. Poorer associated with higher subsequent (cf-PWV 5-year change 0.09, 95% CI 0.03-0.17 per SD lower FEV1) after adjustment for age, sex, ethnicity, heart rate, mean pressure. Decrease (0.17, 0.04-0.30 top compared bottom quartile decline FEV1). There no evidence support circulating CRP (C-reactive protein) or IL (interleukin)-6. Furthermore, accounting status. In conclusion, predicted future stiffness. These findings a clinically important factor provide justification intervention based relationship