The role of glucose 6-phosphate in the control of glycogen synthase.
作者： Carlos Viijlar‐Palasí , Joan J. Guinovart
DOI: 10.1096/FASEBJ.11.7.9212078
关键词:
摘要: Elevated blood glucose concentrations result in increased intracellular levels of 6-phosphate liver, skeletal muscle, and adipose tissue. In are the main factor control synthesis glycogen; insulin has only a potentiating effect. muscle adipocytes, alone little effect on activity glycogen synthase, limiting enzyme synthesis. However, released as elevated stimulates translocation specific transporters to cell membrane, increases uptake glucose, causes covalent, dephosphorylation-mediated activation synthase. We present evidence that contents provoke synthase addition, may inhibit phosphorylation by cyclic AMP-stimulated protein kinase. show stimulated appear play major role enzymes involved
fasebj.org 参考文章(90)
L Agius, Control of glucokinase translocation in rat hepatocytes by sorbitol and the cytosolic redox state Biochemical Journal. ,vol. 298, pp. 237- 243 ,(1994) , 10.1042/BJ2980237
H Flotow, P J Roach, Synergistic phosphorylation of rabbit muscle glycogen synthase by cyclic AMP-dependent protein kinase and casein kinase I. Implications for hormonal regulation of glycogen synthase. Journal of Biological Chemistry. ,vol. 264, pp. 9126- 9128 ,(1989) , 10.1016/S0021-9258(18)60501-0
Duna Massillon, Mathieu Bollen, Henri De Wulf, Kristin Overloop, Florent Vanstapel, Paul Van Hecke, Willy Stalmans, Demonstration of a glycogen/glucose 1-phosphate cycle in hepatocytes from fasted rats. Selective inactivation of phosphorylase by 2-deoxy-2-fluoro-alpha-D-glucopyranosyl fluoride. Journal of Biological Chemistry. ,vol. 270, pp. 19351- 19356 ,(1995) , 10.1074/JBC.270.33.19351
M D Meglasson, F M Matschinsky, Discrimination of glucose anomers by glucokinase from liver and transplantable insulinoma. Journal of Biological Chemistry. ,vol. 258, pp. 6705- 6708 ,(1983) , 10.1016/S0021-9258(18)32274-9
G I Welsh, C G Proud, Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B. Biochemical Journal. ,vol. 294, pp. 625- 629 ,(1993) , 10.1042/BJ2940625
Y H Wang, A W Bell, M A Hermodson, P J Roach, Liver isozyme of rabbit glycogen synthase. Amino acid sequences surrounding phosphorylation sites recognized by cyclic AMP-dependent protein kinase. Journal of Biological Chemistry. ,vol. 261, pp. 16909- 16915 ,(1986) , 10.1016/S0021-9258(19)75975-4
Agustí Salavert, Emilio Itarte, Joan Massaguè, Joan J. Guinovart, Multiple phosphorylation of rabbit muscle glycogen synthase by glycogen synthase kinase-1 FEBS Letters. ,vol. 106, pp. 279- 283 ,(1979) , 10.1016/0014-5793(79)80514-1
J G Foulkes, P Cohen, S J Strada, W V Everson, L S Jefferson, Antagonistic effects of insulin and beta-adrenergic agonists on the activity of protein phosphatase inhibitor-1 in skeletal muscle of the perfused rat hemicorpus. Journal of Biological Chemistry. ,vol. 257, pp. 12493- 12496 ,(1982) , 10.1016/S0021-9258(18)33537-3
J C Lawrence, C James, Activation of glycogen synthase by insulin in rat adipocytes. Evidence of hormonal stimulation of multisite dephosphorylation by glucose transport-dependent and -independent pathways. Journal of Biological Chemistry. ,vol. 259, pp. 7975- 7982 ,(1984) , 10.1016/S0021-9258(17)42888-2
Ronald J. Walkenbach, Richard Hazen, Joseph Larner, Hormonal regulation of glycogen synthase: Insulin decreases protein kinase sensitivity to cyclic AMP Biochimica et Biophysica Acta. ,vol. 629, pp. 421- 430 ,(1980) , 10.1016/0304-4165(80)90148-8