Method of treating drug-resistant cancer
作者： Martha Karen Newell , Elizabeth Villalobos-Menuey , Evan Newell
DOI:
关键词:
摘要: Systems and methods for treating inflammatory proliferative diseases, wounds, using as a pharmacon UCP and/or Fas antibody or other inhibitor, combination thereof, therapeutically acceptable amount of fatty acid metabolism inhibitor glucose optionally in with one more chemotherpeutic agents. In preferred embodiments, the invention combines an against antigen oxirane carboxylic acid, represented by etomoxir, 2-deoxyglucose compound, 2-deoxy-D-glucose. The systems can be used to treat drug-resistant multi-drug resistant cancers.
lens.org 参考文章(203)
Valeria R Fantin, Marcelo J Berardi, Luca Scorrano, Stanley J Korsmeyer, Philip Leder, A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth Cancer Cell. ,vol. 2, pp. 29- 42 ,(2002) , 10.1016/S1535-6108(02)00082-X
M. S. Bitar, Co-Administration of Etomoxir and RU-486 Mitigates Insulin Resistance in Hepatic and Muscular Tissues of STZ-Induced Diabetic Rats Hormone and Metabolic Research. ,vol. 33, pp. 577- 584 ,(2001) , 10.1055/S-2001-17903
Eddie Hu, Alan L. Epstein, Gregory S. Naeve, Indraini Gill, Sue Martin, Andy Sherrod, Peter Nichols, David Chen, Amitabha Mazumder, Alexandra M. Levine, A phase 1a clinical trial of LYM-1 monoclonal antibody serotherapy in patients with refractory b cell malignancies Hematological Oncology. ,vol. 7, pp. 155- 166 ,(1989) , 10.1002/HON.2900070207
Stefan Carrel, Andreas Schmidt-Kessen, Laura Giuffrè, Recombinant interferon-γ can induce the expression of HLA-DR and-DC on DR-negative melanoma cells and enhance the expression of HLA-ABC and tumor-associated antigens European Journal of Immunology. ,vol. 15, pp. 118- 123 ,(1985) , 10.1002/EJI.1830150204
John E. Craighead, Sally A. Huber, Mark K. Haynes, Diverse patterns of immune and non-immune-mediated disease in EMC M-variant-infected mice. Journal of Autoimmunity. ,vol. 3, pp. 27- 29 ,(1990) , 10.1016/S0896-8411(09)90006-3
Ying Wang, Surinder K. Aggarwal, Effects of cisplatin and taxol on inducible nitric oxide synthase, gastrin and somatostatin in gastrointestinal toxicity Anti-Cancer Drugs. ,vol. 8, pp. 853- 858 ,(1997) , 10.1097/00001813-199710000-00006
A Bhushan, JL Kupperman, JE Stone, PJ Kimberly, NS Calman, MP Hacker, RB Birge, TR Tritton, MK Newell, Drug resistance results in alterations in expression of immune recognition molecules and failure to express Fas (CD95) Immunology and Cell Biology. ,vol. 76, pp. 350- 356 ,(1998) , 10.1046/J.1440-1711.1998.00758.X
Sualp Tansan, Yener Ko�, Hayri Aydin, Godofredo Urbano, R. McCaffrey, Augmentation of vincristine cytotoxicity by megestrol acetate Cancer Chemotherapy and Pharmacology. ,vol. 39, pp. 333- 340 ,(1997) , 10.1007/S002800050580
Charles C Horn, Hong Ji, Mark I Friedman, Etomoxir, a fatty acid oxidation inhibitor, increases food intake and reduces hepatic energy status in rats. Physiology & Behavior. ,vol. 81, pp. 157- 162 ,(2004) , 10.1016/J.PHYSBEH.2004.01.007
Carolina Molero, Antonio de Lucas, Juan F. Rodríguez, Recovery of polyols from flexible polyurethane foam by “split-phase” glycolysis: Glycol influence Polymer Degradation and Stability. ,vol. 91, pp. 221- 228 ,(2006) , 10.1016/J.POLYMDEGRADSTAB.2005.05.008