Blood pressure and menopausal transition

摘要: Objective Blood pressure changes during menopausal transition have not been studied previously using a biracial sample. We invesigated whether was associated with change in blood African-American or white women. Design, setting and participants The prospective multicenter study, the Atherosclerosis Risk In Communities (ARIC) Study (1987-95) utilized. Included were never-users of hormone replacement therapy (3800 women, 44% original sample). Main outcome measure Changes adjusted for baseline age body mass index, pressure, antihypertensive use, ARIC field center weight change. group compared to non-transition group, separately, by ethnicity. Results Women undergoing did differ significantly regard systolic [5.2, 95% confidence interval (Cl) 4.0-6.4] from non-transitional women (4.6, Cl 4.0-5.2); adjustment age, other factors alter this finding. Transitional had less diastolic (-0.5, - 1.1 0.2) than (-2.0, 2.4 -1.7, P= 0.000) but, after covariates, result significant (P= 0.003) higher but difference became non-significant 0.21) restricting sample younger 55 years age. Interactions between ethnicity significant, either Conclusion Menopausal is