Doxorubicin-induced apoptosis in germinal vesicle (GV) oocytes.
作者： Hadas Bar-Joseph , Irit Ben-Aharon , Shulamith Rizel , Salomon M. Stemmer , Moran Tzabari
DOI: 10.1016/J.REPROTOX.2010.07.003
关键词:
摘要: Ovarian failure is a-known side-effect observed in women treated for cancer. Doxorubicin (DXR) was found to be detrimental MII mouse oocytes. We aimed at characterizing the effect of DXR on germinal vesicle (GV) oocytes that comprise majority within ovaries encountering chemotherapy. Mouse follicles and were exposed vitro. localization its possible cellular targets examined by fluorescence confocal microscopy. demonstrated crosses blood-follicle barrier accumulates granulosa cells. The mechanism DXR-induced apoptosis involves chromosomal disintegration, activation mitochondria followed PERK caspase-12 inactivation PARP. follicular GV more vulnerable toxic than ovulated suggest elicits apoptotic signal mitochondria, induction ER-stress a increase intracellular calcium.
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