New quinolinic derivatives as centrally active antioxidants.

作者: Gilbert Dorey , Brian Lockhart , Pierre Lestage , Patrick Casara

DOI: 10.1016/S0960-894X(00)00122-0

关键词:

摘要: A series of new 1,2-dihydro and 1,2,3,4-tetrahydroquinolines, synthesized from the corresponding propargylaniline intermediates, have been developed as antioxidants for potential treatment pathologies implicating central oxidative stress.

参考文章(23)
Edward D. Hall, Antioxidant Therapeutic Strategies in CNS Disorders Springer, Boston, MA. pp. 325- 339 ,(1997) , 10.1007/978-1-4899-0197-2_17
F Houlihan, F Bouchard, JMJ Frechet, C Gi Willson, Phase transfer catalysis in the tert-butyloxycarbonylation of alcohols, phenols, enols, and thiols with di-tert-butyl dicarbonate Canadian Journal of Chemistry. ,vol. 63, pp. 153- 162 ,(1985) , 10.1139/V85-025
G. W. Burton, K. U. Ingold, Autoxidation of biological molecules. 1. Antioxidant activity of vitamin E and related chain-breaking phenolic antioxidants in vitro Journal of the American Chemical Society. ,vol. 103, pp. 6472- 6477 ,(1981) , 10.1021/JA00411A035
Barry Halliwell, John M. C. Gutteridge, Free radicals in biology and medicine ,(1985)
Janneche Utne Skaare, Inger Nafstad, The Distribution of 14C-Ethoxyquin in Rat Pharmacology & Toxicology. ,vol. 44, pp. 303- 307 ,(2009) , 10.1111/J.1600-0773.1979.TB02334.X
Frank D. Gunstone, Raphael C. Mordi, Snorri Thorisson, John C. Walton, Richard A. Jackson, EPR study of radical intermediates from the oxidation of 6-ethoxy-2,2,4-trimethyl- and 6-ethoxy-2,2,4,8-tetramethyl-1,2-dihydroquinoline Journal of The Chemical Society-perkin Transactions 1. pp. 1955- 1958 ,(1991) , 10.1039/P29910001955
Isamu Saito, Takao Asano, Keiji Sano, Kintomo Takakura, Hiroshi Abe, Takashi Yoshimoto, Haruhiko Kikuchi, Tomio Ohta, Sadahiko Ishibashi, Neuroprotective Effect of an Antioxidant, Ebselen, in Patients with Delayed Neurological Deficits after Aneurysmal Subarachnoid Hemorrhage Neurosurgery. ,vol. 42, pp. 269- 277 ,(1998) , 10.1097/00006123-199802000-00038
Timothy H. Murphy, Masaomi Miyamoto, Antonio Sastre, Ronald L. Schnaar, Joseph T. Coyle, Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress Neuron. ,vol. 2, pp. 1547- 1558 ,(1989) , 10.1016/0896-6273(89)90043-3