Differential regulation of cardiac expression of IL-6 and TNF-α by A2- and A3-adenosine receptors
作者： Daniel R. Wagner , Toru Kubota , Virginia J. Sanders , Charles F. McTiernan , Arthur M. Feldman
DOI: 10.1152/AJPHEART.1999.276.6.H2141
关键词:
摘要: The proinflammatory cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 have been implicated in the development of congestive heart failure. Adenosine inhibits expression TNF-alpha IL-6 macrophages. We determined effect adenosine on cytokine rat cardiomyocytes trabecular muscles obtained from patients with cardiomyopathy. In myocytes, suppressed mRNA by 40% (P < 0.05) induced a 4.7-fold increase twofold protein release 0.001). could be replicated A2 agonist. A3 agonist, but not A1 agonists, was completely antagonist. human muscles, agonist 60% 0.05), had no IL-6. failing heart, immunolocalized to inflammatory cells. Thus receptors differentially regulate cardiac Rat respond differently adenosine.
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