Electron transfer dissociation of sodium cationized polyesters: Reaction time effects and combination with collisional activation and ion mobility separation
作者： Jonathan P. Williams , Kirsten Craven , Jeffery M. Brown , Chrys Wesdemiotis , Bryan C. Katzenmeyer
DOI: 10.1016/J.IJMS.2014.09.021
关键词:
摘要: Abstract The electron transfer dissociation (ETD) characteristics of doubly sodiated polylactide were investigated at varying ion–ion reaction times, ranging from 20 to 220 ms. ETD product ion yields and signal-to-noise ratio maximized the shortest time. At longer extent Na/H or H/Na exchange reactions rose, causing spectral crowding; in addition, sensitivity decreased significantly due losses neutralization scattering. quadrupole trap (QIT) quadrupole/time-of-flight (Q/ToF) mass spectrometers using fluoranthene p -nitrotoluene reagent anions, respectively, led similar ions. Q/ToF configuration allowed for collisionally activated (CAD) total current under mild activation conditions, which gave rise new more abundant fragment distributions by mainly depleting residual reduced precursor ETD/CAD fragmentation patterns markedly different fragments generated simple CAD, thereby providing complementary structural information about analyzed polyester. collision cross-sections major series, determined mobility spectrometry (IM–MS) experiments on instrument, agreed well with linear architectures expected radical-induced cleavages (CO)-O-alkyl bonds promoted added event.
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