Submandibular Gland Peptide-T (SGP-T) Inhibits Intestinal Anaphylaxis

摘要: A novel peptide, submandibular gland peptide-T(SGP-T), which reduces allergen-induced hypotension, wasexamined for effects on intestinal anaphylaxis.Hooded-Lister rats were sensitized to egg albumin and prepared the measurement of in vivomyoelectric activity jejunum. The disruption ofmigrating myoelectric complexes (MMCs) that occurs uponintraluminal, duodenal challenge with antigen was inhibited by 75% uponintravenous treatment 100 μg/kg SGP-T. Inaddition, SGP-T reduced number experiencinganaphylactic diarrhea disrupted MMCs, but thepeptide did not alter antigen-provoked release ratmast cell protease II. mechanism action SGP-Tremains be determined, it apparently does actdirectly mast cells exert its antianaphylactic action. These results emphasize modulationof immediate hypersensitivity reactions is only one ofseveral gastrointestinal activities are affected bygrowth factors peptides released from salivary glands.