Generalized epilepsy syndromes and callosal thickness: Differential effects between patients with juvenile myoclonic epilepsy and those with generalized tonic-clonic seizures alone

摘要: Abstract Purpose The definition of two well-studied genetic generalized epilepsy syndromes (GGE) − juvenile myoclonic (JME) and with tonic-clonic seizures alone (GTCS) suggests the absence structural cerebral abnormalities. Nevertheless, there are various reports such abnormalities (especially in JME), where effects mainly occur within thalamus mesial prefrontal regions. This raises question whether JME is particularly linked to midline structure abnormalities, which may also involve corpus callosum. Method We studied callosal morphology a well-matched sample 22 patients, 15 GTCS 42 controls (CTL) for all whom we obtained T1-weighted data on 3 T MRI scanner. More specifically, measured thickness at 100 equidistant points across surface, subsequently compared three groups (JME, GTCS, CTL) against each other. Results Significant differences between patients were observed genu, anterior midbody, isthmus, thinner regions patients. There no significant controls, not Conclusion present outcomes point suggesting an impairment interhemisperic communication prefrontal, motor, parietal temporal cortices. These findings further support notion that aberrations differentiated GGE syndromes, deviations from normality JME.