摘要: Over the last two decades, progress towards new drugs for treatment of Chagas' disease has been disappointing. However, as a result parasite genome sequencing projects, possibility identifying novel drug targets through genomics, proteomics and bioinformatics never better. Progress development therapeutics, from target identification validation by chemical genetic means to rational design, is illustrated with reference metabolism functions trypanothione, particular emphasis on trypanothione reductase, one current choice.
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