Pharmacogenetics and anaesthesia: the value of genetic profiling
作者： R. Landau , L. A. Bollag , J. C. Kraft
DOI: 10.1111/J.1365-2044.2011.06918.X
关键词:
摘要: Summary Approximately 50 years ago, pharmacogenetics was described as a new field of medicine that may explain human drug action. Anaesthesia played key role in the early investigations. An understanding how person’s DNA influences metabolism and effectiveness allow individually tailored prescriptions, improving outcomes safety. The ultimate goal pharmacogenetic research is to offer personalised improve both efficacy medication patient safety by helping predict risk adverse outcomes. In this review, we present selection historical landmarks where anaesthesia has been catalyst for development. We examine level evidence cite examples candidate genes common polymorphisms known alter response peri-operative medication. Finally, set forth current views potential exciting perspectives arise from application daily practice pain medicine.
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