Preparation and evaluation of a Rubropunctatin-loaded liposome anticancer drug carrier
作者： Dongling Xu , Jiming Xie , Xiaolian Feng , Xiaofang Zhang , Zhenzhen Ren
DOI: 10.1039/C9RA10390B
关键词:
摘要: Rubropunctatin is a naturally occurring constituent of polyketide compounds that has great potential in the development cancer-assisted chemotherapy. However, it certain shortcomings such as water insolubility and photo instability limit its clinical application. In this study, we constructed Rubropunctatin-loaded liposome (R-Liposome) anticancer drug carrier for first time. The results indicate R-Liposome soluble, spherical morphology, homogeneity dispersibility with high encapsulation efficiency (EE%, 90 ± 3.5%) loading rate (LR%, 5.60 2.5%) values. Moreover, improves photostability, storage pH stabilities Rubropunctatin. also prolongs release Rubropunctatin, enhances activity encourages mechanism to promote apoptosis. Therefore, liposomal nanoparticles have delivery vehicles cancer treatment.
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