The Effects of Acute Exposure to Prolonged Sitting, With and Without Interruption, on Vascular Function Among Adults: A Meta-analysis

作者: Craig Paterson , Simon Fryer , Gabriel Zieff , Keeron Stone , Daniel P. Credeur

DOI: 10.1007/S40279-020-01325-5

关键词:

摘要: Exposure to acute prolonged sitting can result in vascular dysfunction, particularly within the legs. This assessed using flow-mediated dilation (FMD), is likely consequence of decreased blood flow-induced shear stress. With mixed success, several interruption strategies have been trialled preserve function. The objectives this meta-analysis were (1) assess effects exposure on function upper- and lower-limb arteries, (2) evaluate effectiveness preserving Sub-group analyses conducted determine whether artery location or modality explain heterogeneity. Electronic databases (PubMed, Web Science, SPORTDiscus, Google Scholar) searched from inception January 2020. Reference lists eligible studies relevant reviews also checked. Inclusion criteria for objective were: (i) FMD% was pre- post-sitting; (ii) either randomised-controlled, randomised-crossover, quasi-experimental trials; (iii) period was ≥ 1 h; (iv) participants healthy non-smoking adults (≥ 18 years), free vascular-acting medication disease at time testing. Additional inclusion strategy must during period; there a control (uninterrupted sitting) group/arm; involved actively moving their lower- upper-limbs. One thousand eight hundred two articles identified, which 17 (22 trials, n = 269) met (1). Of those articles, 6 (9 n = 127) (2). Weighted mean differences (WMD), 95% confidence intervals (95% CI), standardised difference (SMD) calculated all trials random-effects modelling. SMD used magnitude effect, where < 0.2, 0.2, 0.5, 0.8 defined as trivial, small, moderate, large respectively. Random-effects modelling showed uninterrupted bouts resulted significant decrease (WMD = − 2.12%, CI − 2.66 − 1.59, SMD = 0.84). Subgroup analysis revealed reductions but not upper-limb FMD%. that interrupting significantly higher compared (WMD = 1.91%, 0.40 3.42, SMD = 0.57). failed identify an optimum moderate non-significant aerobic interventions (WMD = 2.17%, − 0.34 4.67, SMD = 0.69) simple resistance activities (WMD = 2.40%, − 0.08 4.88, SMD = 0.55) trivial effect standing interruptions (WMD = 0.24%, − 0.90 1.38, SMD = 0.16). leads dysfunction arteries lower, upper, limbs. limited available data indicate be prevented by regularly sitting, with activities.

参考文章(72)
Julian P. T. Higgins, Sally Green, Cochrane Handbook for Systematic Reviews of Interventions ,(2019)
Ali M McManus, Philip N Ainslie, Daniel J Green, Ryan G Simair, Kurt Smith, Nia Lewis, None, Impact of prolonged sitting on vascular function in young girls Experimental Physiology. ,vol. 100, pp. 1379- 1387 ,(2015) , 10.1113/EP085355
Aviroop Biswas, Paul I. Oh, Guy E. Faulkner, Ravi R. Bajaj, Michael A. Silver, Marc S. Mitchell, David A. Alter, Sedentary Time and Its Association With Risk for Disease Incidence, Mortality, and Hospitalization in Adults: A Systematic Review and Meta-analysis Annals of Internal Medicine. ,vol. 162, pp. 123- 132 ,(2015) , 10.7326/M14-1651
Dick HJ Thijssen, Ellen A Dawson, Mark A Black, Maria TE Hopman, N Timothy Cable, Daniel J Green, None, Heterogeneity in conduit artery function in humans: impact of arterial size American Journal of Physiology-heart and Circulatory Physiology. ,vol. 295, ,(2008) , 10.1152/AJPHEART.00405.2008
Lee Stoner, James Faulkner, Manning J. Sabatier, Is allometric scaling really a panacea for flow-mediated dilation? Commentary on paper by Atkinson and Batterham. Atherosclerosis. ,vol. 228, pp. 280- 281 ,(2013) , 10.1016/J.ATHEROSCLEROSIS.2013.02.001
Yang Xu, Rakesh C. Arora, Brett M. Hiebert, Blake Lerner, Andrea Szwajcer, Kerry McDonald, Claudio Rigatto, Paul Komenda, Manish M. Sood, Navdeep Tangri, Non-invasive endothelial function testing and the risk of adverse outcomes: a systematic review and meta-analysis European Journal of Echocardiography. ,vol. 15, pp. 736- 746 ,(2014) , 10.1093/EHJCI/JET256
Janet P. Wallace, Antioxidant Vitamin C Prevents Decline in Endothelial Function during Sitting Medical Science Monitor. ,vol. 21, pp. 1015- 1021 ,(2015) , 10.12659/MSM.893192
Caroline Cheng, Dennie Tempel, Rien van Haperen, Arjen van der Baan, Frank Grosveld, Mat J.A.P. Daemen, Rob Krams, Rini de Crom, Atherosclerotic Lesion Size and Vulnerability Are Determined by Patterns of Fluid Shear Stress Circulation. ,vol. 113, pp. 2744- 2753 ,(2006) , 10.1161/CIRCULATIONAHA.105.590018
Lee Stoner, Manning J Sabatier, Use of ultrasound for non-invasive assessment of flow-mediated dilation. Journal of Atherosclerosis and Thrombosis. ,vol. 19, pp. 407- 421 ,(2012) , 10.5551/JAT.11395
Daren K. Heyland, Shaun MacDonald, Laurie Keefe, John W. Drover, Total Parenteral Nutrition in the Critically Ill Patient: A Meta-analysis JAMA. ,vol. 280, pp. 2013- 2019 ,(1998) , 10.1001/JAMA.280.23.2013