作者: Craig Paterson , Simon Fryer , Gabriel Zieff , Keeron Stone , Daniel P. Credeur
DOI: 10.1007/S40279-020-01325-5
关键词:
摘要: Exposure to acute prolonged sitting can result in vascular dysfunction, particularly within the legs. This assessed using flow-mediated dilation (FMD), is likely consequence of decreased blood flow-induced shear stress. With mixed success, several interruption strategies have been trialled preserve function. The objectives this meta-analysis were (1) assess effects exposure on function upper- and lower-limb arteries, (2) evaluate effectiveness preserving Sub-group analyses conducted determine whether artery location or modality explain heterogeneity. Electronic databases (PubMed, Web Science, SPORTDiscus, Google Scholar) searched from inception January 2020. Reference lists eligible studies relevant reviews also checked. Inclusion criteria for objective were: (i) FMD% was pre- post-sitting; (ii) either randomised-controlled, randomised-crossover, quasi-experimental trials; (iii) period was ≥ 1 h; (iv) participants healthy non-smoking adults (≥ 18 years), free vascular-acting medication disease at time testing. Additional inclusion strategy must during period; there a control (uninterrupted sitting) group/arm; involved actively moving their lower- upper-limbs. One thousand eight hundred two articles identified, which 17 (22 trials, n = 269) met (1). Of those articles, 6 (9 n = 127) (2). Weighted mean differences (WMD), 95% confidence intervals (95% CI), standardised difference (SMD) calculated all trials random-effects modelling. SMD used magnitude effect, where < 0.2, 0.2, 0.5, 0.8 defined as trivial, small, moderate, large respectively. Random-effects modelling showed uninterrupted bouts resulted significant decrease (WMD = − 2.12%, CI − 2.66 − 1.59, SMD = 0.84). Subgroup analysis revealed reductions but not upper-limb FMD%. that interrupting significantly higher compared (WMD = 1.91%, 0.40 3.42, SMD = 0.57). failed identify an optimum moderate non-significant aerobic interventions (WMD = 2.17%, − 0.34 4.67, SMD = 0.69) simple resistance activities (WMD = 2.40%, − 0.08 4.88, SMD = 0.55) trivial effect standing interruptions (WMD = 0.24%, − 0.90 1.38, SMD = 0.16). leads dysfunction arteries lower, upper, limbs. limited available data indicate be prevented by regularly sitting, with activities.