Peritoneal transport in CAPD patients with permanent loss of ultrafiltration capacity

摘要: Peritoneal transport in CAPD patients with permanent loss of ultrafiltration capacity. During a 10 year period, 14 out 227 (6.2%) undergoing continuous ambulatory peritoneal dialysis (CAPD) developed capacity (UFC). The risk UFC increased from 2.6% after one to 30.9% six years treatment. A hour, single dwell study glucose 3.86% fluid was carried nine the and 18 normal UFC. Intraperitoneal dialysate volumes were calculated using 131 I-tagged albumin (RISA) as volume marker correction applied for its elimination cavity. RISA coefficient (K E ), which can serve an estimation upper limit lymphatic flow, also calculated. Diffusive mass coefficients BD ) investigated solutes (glucose, creatinine, urea, potassium, total protein, β2-microglobulin) during period isovolemia. Two patterns observed: (a) seven had high K values small resulting rapid uptake glucose, whereas proteins normal; (b) two but threefold increase both reabsorption rate . We conclude that osmotic driving force (due diffusive solutes) (possibly due reabsorption) are major causes patients.