Promotion of osteoclast differentiation and activation in spite of impeded osteoblast-lineage differentiation under acidosis: effects of acidosis on bone metabolism.
作者： Kato
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摘要: The acidosis that accompanies many diseases and pathological conditions can promote osteoclast formation activation. Acidosis mainly acts on the last phase of to generate large osteoclasts bone resorption. There are several acid-sensing mechanisms, among which transient receptor potential (TRP) channels G protein-related receptors have been focused on. TRPV4 appear be, at least partly, implicated in acidosis-promoted formation. Other TRP including TRPV1 TRPV2 might be components machinery. Several reports suggest involvement ovarian cancer protein-coupled 1 (OGR1), a G-protein-related acid sensor, activator nuclear factor kappa-B ligand (RANKL) expression via cyclooxygenase-2 (COX-2). On other hand, impairs osteoblast differentiation, is further impeded presence inflammatory cytokines.
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