Anti-Ma and anti-Ta associated paraneoplastic neurological syndromes: 22 newly diagnosed patients and review of previous cases

摘要: Background: Paraneoplastic neurological syndromes (PNS) are indirect remote effects of cancer on the nervous system, often associated with presence specific serum antibodies. The most recently described PNS defining reactivity is anti-Ma/anti-Ta. Here we present 22 newly diagnosed patients anti-Ma or anti-Ta reactivity, refine clinical picture and review all published to date. Patients methods: were identified by testing for PNMA1 PNMA2 antibodies western blotting immunofluorescence. Clinical data obtained either referral patient from referring physicians. Results: Analysis new (14 anti-Ma, eight anti-Ta) confirmed that usually found in young men limbic encephalitis testicular germ cell tumours who stabilise neurologically long term survival after tumour treatment. sex, middle-aged, presented a range symptoms had limited response Furthermore, expanded features: (1) peripheral system may be involved; (2) an overlap anti-Hu possible; (3) manifestation can extragonadal detectable only at orchiectomy. Conclusion: Refining expanding anti-Ma/anti-Ta presentations clearly demonstrated distinction between high relevance.