Memory trace replay: The shaping of memory consolidation by neuromodulation

摘要: The consolidation of memories for places and events is thought to rely, at the network level, on replay spatially tuned neuronal firing patterns representing discrete spatial trajectories. This occurs in hippocampal-entorhinal circuit during sharp wave ripple (SWRs) that occur sleep or rest. Here, we review theoretical models lingering place cell excitability behaviorally induced synaptic plasticity within assemblies explain which sequences are replayed. We further provide new insights into how fluctuations cholinergic tone different behavioral states might shape direction dopaminergic release response novelty reward can modulate