Use of selective toxins to separate surface and tubular sodium currents in frog skeletal muscle fibers.
作者： N. Arispe , E. Jaimovich , J. L. Liberona , E. Rojas
DOI: 10.1007/BF00581639
关键词:
摘要: The interaction between toxin γ from the venom of scorpionTityus serrulatus and sodium channels in skeletal muscle membranes frogCaudiverbera caudiverbera was studied. Sodium current cut sartorius fibers is a complex signal which early late components are difficult to separate. External application Tityus initially blocked component voltage-dependent manner. Longer exposure induced complete blockade two inward current. Application tetrodotoxin pretreated with at submaximal concentrations allowed observation distinct Binding of125I-labelled highly purified membrane fractions same used establish presence high affinit receptors both transverse-tubular surface membrane.
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