Synthesis of β-Ketosulfone Derivatives As New Non-Cytotoxic Urease Inhibitors In Vitro.

摘要: BACKGROUND Peptic ulcer and urolithiasis are largely due to infection caused by ureaseproducing bacteria. Therefore, the discovery of urease inhibitors is an important area medicinal chemistry research. OBJECTIVE The main aim work was identify novel with no cytotoxicity. METHODS During current study, a series β-ketosulfones 1-26 synthesized in two steps evaluated for their vitro inhibition potential. RESULTS Out twenty-six compounds, seventeen have shown good significant inhibitory activity IC50 values ranging between 49.93-351.46 µM, comparison standard thiourea (IC50 = 21 ± 0.11 µM). Moreover, all compounds found be non-cytotoxic against normal 3T3 cell line. CONCLUSION This study has identified as inhibitors.