摘要: The author analyzes parkinsonism and hyperkinesia in psychiatric patients with tardive dyskinesia before during treatment alpha-methyl-p-tyrosine (AMPT, a dopamine antagonist), biperiden (an acetylcholine baclofen (a GABA agonist); paralysis agitans L-dopa-induced hyperkinesia. AMPT had similar influences on oral dyskinesia, resulting reduced frequency, unchanged or slightly amplitude, increased duration of each movement. concludes that: 1) dopaminergic activity may be the primary pathogenetic background for dyskinesia; 2) hypersensitivity and/or cholinergic hypofunction is necessary breaks through; 3) neurotoxic effects neuroleptics associated age-dependent changes nigrostriatal regions representing innervation.
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