Involvement of Toll-like receptor 4 in the embryogenesis of the rodent filaria Litomosoides sigmodontis
作者： Kenneth M. Pfarr , Kerstin Fischer , Achim Hoerauf
DOI: 10.1007/S00430-002-0159-5
关键词:
摘要: To examine the role that lipopolysaccharide (LPS)-like molecules from filarial intracellular endobacteria Wolbachia might play in development of infections, a natural infection LPS-nonresponsive C3H/HeJ mouse strain was compared to LPS-responsive C3H/HeN strain. mice have been shown be susceptible rodent nematode Litomosoides sigmodontis, with adult worms including females containing mature microfilariae (first stage larvae) uterine tubes. However, free are not detected. In this study worm burden and length were significantly different between mice. fertility CeH/HeJ found higher than those Significantly, at site only These results indicate for TLR4 signaling immune response inhibits embryogenesis prevents release or directly kills released microfilariae.
springer.com
sci-hub.se 参考文章(22)
Yonca Bulut, Emmanuelle Faure, Lisa Thomas, Hisae Karahashi, Kathrin S. Michelsen, Ozlem Equils, Sandra G. Morrison, Richard P. Morrison, Moshe Arditi, Chlamydial heat shock protein 60 activates macrophages and endothelial cells through Toll-like receptor 4 and MD2 in a MyD88-dependent pathway. Journal of Immunology. ,vol. 168, pp. 1435- 1440 ,(2002) , 10.4049/JIMMUNOL.168.3.1435
Koji Ohashi, Volker Burkart, Stefanie Flohé, Hubert Kolb, Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex The Journal of Immunology. ,vol. 164, pp. 558- 561 ,(2000) , 10.4049/JIMMUNOL.164.2.558
Achim Hoerauf, Sabine Mand, Ohene Adjei, Bernhard Fleischer, Dietrich W Büttner, Depletion of wolbachia endobacteria in Onchocerca volvulus by doxycycline and microfilaridermia after ivermectin treatment. The Lancet. ,vol. 357, pp. 1415- 1416 ,(2001) , 10.1016/S0140-6736(00)04581-5
Norbert W. Brattig, Ulf Rathjens, Martin Ernst, Frank Geisinger, Alfons Renz, Frank W. Tischendorf, Lipopolysaccharide-like molecules derived from Wolbachia endobacteria of the filaria Onchocerca volvulus are candidate mediators in the sequence of inflammatory and antiinflammatory responses of human monocytes. Microbes and Infection. ,vol. 2, pp. 1147- 1157 ,(2000) , 10.1016/S1286-4579(00)01269-7
Danielle Malo, Line Larivière, Stefanie N. Vogel, Andrei Medvedev, Salman T. Qureshi, Pin-Yu Perera, Dabney Johnson, Cutting edge: functional characterization of the effect of the C3H/HeJ defect in mice that lack an Lpsn gene: in vivo evidence for a dominant negative mutation. Journal of Immunology. ,vol. 162, pp. 5666- 5670 ,(1999)
P. MARECHAL, L. LE GOFF, W. HOFFMAN, J. RAPP, I.P. OSWALD, C. OMBROUCK, D.W. TAYLOR, O. BAIN, G. PETIT, Immune response to the filaria Litomosoides sigmodontis in susceptible and resistant mice. Parasite Immunology. ,vol. 19, pp. 273- 279 ,(1997) , 10.1046/J.1365-3024.1997.D01-209.X
Norbert W. Brattig, Dietrich W. Büttner, Achim Hoerauf, Neutrophil accumulation around Onchocerca worms and chemotaxis of neutrophils are dependent on Wolbachia endobacteria. Microbes and Infection. ,vol. 3, pp. 439- 446 ,(2001) , 10.1016/S1286-4579(01)01399-5
Helen F Cross, Melang Haarbrink, Gill Egerton, Maria Yazdanbakhsh, Mark J Taylor, Severe reactions to filarial chemotherapy and release of Wolbachia endosymbionts into blood. The Lancet. ,vol. 358, pp. 1873- 1875 ,(2001) , 10.1016/S0140-6736(01)06899-4
O. Bain, S. Wanji, P.N. Vuong, P. Maréchal, L. Le Goff, G. Petit, Plateaux S., Dumarquez E., Chrétien F., Larval biology of six filariae of the sub-family Onchocercinae in a vertebrate host Parasite. ,vol. 1, pp. 241- 254 ,(1994) , 10.1051/PARASITE/1994013241
Achim Hoerauf, Lars Volkmann, Christoph Hamelmann, Ohene Adjei, Ingo B Autenrieth, Bernhard Fleischer, Dietrich W Büttner, Endosymbiotic bacteria in worms as targets for a novel chemotherapy in filariasis The Lancet. ,vol. 355, pp. 1242- 1243 ,(2000) , 10.1016/S0140-6736(00)02095-X