Changes in pre- and postoperative serum leptin concentrations in dogs with gallbladder mucocele and cholelithiasis

摘要: Leptin has been shown to have various physiological and pathological roles in the canine gallbladder. In this study, we performed pre- postoperative short-term follow-up analyses confirm changes serum leptin levels before after cholecystectomy due gallbladder mucocele (GBM) or cholelithiasis dogs. Twenty-six cholecystectomized dogs (GBM: n = 14; cholelithiasis: n = 12) for prophylactic clinical symptom relief were enrolled present study. Dogs subgrouped according symptoms prognosis surgery as follows: 1) asymptomatic group (n = 13), 2) recovery (n = 8), 3) death (n = 5). Liver enzymes, total bilirubin, lipid profiles, concentrations determined from sera on pre-operative day at 1, 3, 7 days postoperation. Serum gradually but significantly decreased (p = 0.008, 0.004, 0.004 days 7, respectively, compared with that surgery) (p = 0.048 0.048 3 surgery). However, group, did not differ over time (p = 0.564). Additionally, (p = 0.006) (p = 0.021) higher than those group. enzymes bilirubin (T-Bil) only particularly 7. liver T-Bil changed time, was Total cholesterol triglyceride all groups. These results indicate is a potential biomarker reflecting severity of GBM both