Comorbidity measurement in patients with laryngeal squamous cell carcinoma.

摘要: Introduction: The evaluation of a cancer patient can be affected by many factors. Cancer patients often have other diseases or medical conditions in addition to their cancer. These are referred as comorbidities. They influence the treatment option, rate complications, outcome, and confound survival analysis. Objective: It was aim this study measure comorbidities with laryngeal squamous cell carcinoma. Patients Methods: Ninety adult treated for newly diagnosed carcinoma were studied. We measured comorbid illness applying following validated scales: Cumulative Illness Rating Scale (CIRS), Kaplan-Feinstein Classification (KFC), Charlson index, Index Coexistent Disease (ICED), Adult Comorbidity Evaluation-27 (ACE-27), Alcohol-Tobacco-Related Comorbidities (ATC), Washington University Head Neck (WUHNCI). Survival analysis performed using Kaplan-Meier method (with log-rank test value being used compare groups). Cox proportional hazards model chosen identify independent prognostic Results: mean age 62.3 years. majority (36.7%) had early tumors. Forty surgery only, while remaining 49 also received postoperative radiation therapy. Only 5 (5.6%) lost follow-up. Median follow-up time 42.5 months. 4-year overall 63%. There statistically significant difference between rates according clinical stage (CS I 87.3%, CS II 48.9%, III 74.7%, IV 23.9%; p Conclusion: comorbidity is an factor surgically In univariate analysis, all indexes able stratify patients. However, multiple only CIRS predictive death. important survival.