Central and peripheral endogenous morphine

摘要: Morphine was first identified in opium from Papaver somniferum, and is still one of the strongest known analgesic compounds used hospital. Since beginning 80s, endogenous morphine, with an identical structure to that morphine isolated poppies, has been characterised numerous mammalian cells tissues. In mammals, biosynthesis associated dopamine, as demonstrated SH-SY5Y human neuronal catecholamine-producing cell line. More recently, morphine-6-glucuronide shown be present neuroblastoma line secreted large dense core vesicles response nicotine stimulation via a Ca 2+ -dependent mechanism suggesting its implication neurotransmission. An increasing number publications have presence different biological processes at central peripheral levels. The review reports major data concerning physiological processes.