Silica/quercetin sol–gel hybrids as antioxidant dental implant materials

摘要: The development of biomaterials with intrinsic antioxidant properties could represent a valuable strategy for preventing the onset peri-implant diseases. In this context, quercetin, naturally occurring flavonoid, has been entrapped at different weight percentages in silica-based inorganic material by sol–gel route. establishment hydrogen bond interactions between flavonol and solid matrix was ascertained Fourier transform infrared spectroscopy. This technique also evidenced changes stretching frequencies quercetin dienonic moiety, suggesting that formation secondary product occurs. Scanning electron microscopy applied to detect morphology synthesized materials. Their bioactivity shown hydroxyapatite layer on sample surface soaked fluid simulates composition human blood plasma. When potential release determined liquid chromatography coupled ultraviolet electrospray ionization tandem mass spectrometry techniques, eluates displayed retention time 0.5 min less than quercetin. Collision-activated dissociation untraviolet-visible spectroscopy were accordance derivative. antiradical investigated systems evaluated DPPH ABTS methods, whereas 2,7-dichlorofluorescein diacetate assay highlighted their ability inhibit H2O2-induced intracellular production reactive oxygen species NIH-3T3 mouse fibroblast cells. Data obtained, along data gathered from MTT cytotoxicity test, revealed materials highest amount showed notable effectiveness.