Gender-specific DNA methylome analysis of a Han Chinese longevity population.

摘要: Human longevity is always a biological hotspot and so much effort has been devoted to identifying genes genetic variations associated with longer lives. Most of the demographic studies have highlighted that females life span than males. The reasons for this are not entirely clear. In study, we carried out pool-based, epigenome-wide investigation DNA methylation profiles in male female nonagenarians/centenarians using Illumina 450 K Methylation Beadchip assays. Although no significant difference was detected average levels examined CpGs (or probes) between samples, number differentially methylated probes (DMPs) were identified, which appeared be enriched certain chromosome regions parts genes. Further analysis DMP-containing (named DMGs) revealed almost all them solely hypermethylated or hypomethylated. Functional enrichment these DMGs indicated hypermethylation hypomethylation may regulate involved different processes, such as hormone regulation, neuron projection, disease-related pathways. This first explore gender-based methylome nonagenarians/centenarians, provide new insights into complex mechanism gender gap human beings.