Hybrid modeling as a QbD/PAT tool in process development: an industrial E. coli case study.

作者: Moritz von Stosch , Jan-Martijn Hamelink , Rui Oliveira

DOI: 10.1007/S00449-016-1557-1

关键词:

摘要: … artificial neural network that describes biomass and product formation rates as function of varied fed-batch … 4a–c), which is a common characteristic of fed-batch processes [45]. …

参考文章(45)
Jukka Rantanen, Johannes Khinast, The Future of Pharmaceutical Manufacturing Sciences. Journal of Pharmaceutical Sciences. ,vol. 104, pp. 3612- 3638 ,(2015) , 10.1002/JPS.24594
Ana P Teixeira, Carlos Alves, Paula M Alves, Manuel JT Carrondo, Rui Oliveira, Hybrid elementary flux analysis/nonparametric modeling: application for bioprocess control. BMC Bioinformatics. ,vol. 8, pp. 30- 30 ,(2007) , 10.1186/1471-2105-8-30
G L Kleman, W R Strohl, Acetate metabolism by Escherichia coli in high-cell-density fermentation. Applied and Environmental Microbiology. ,vol. 60, pp. 3952- 3958 ,(1994) , 10.1128/AEM.60.11.3952-3958.1994
James Gomes, Viki R. Chopda, Anurag S. Rathore, Integrating systems analysis and control for implementing process analytical technology in bioprocess development Journal of Chemical Technology & Biotechnology. ,vol. 90, pp. 583- 589 ,(2015) , 10.1002/JCTB.4591
Dimitris C. Psichogios, Lyle H. Ungar, A hybrid neural network‐first principles approach to process modeling Aiche Journal. ,vol. 38, pp. 1499- 1511 ,(1992) , 10.1002/AIC.690381003
Jarka Glassey, Krist V. Gernaey, Christoph Clemens, Torsten W. Schulz, Rui Oliveira, Gerald Striedner, Carl-Fredrik Mandenius, Process analytical technology (PAT) for biopharmaceuticals Biotechnology Journal. ,vol. 6, pp. 369- 377 ,(2011) , 10.1002/BIOT.201000356
Bieke Dejaegher, Yvan Vander Heyden, Experimental designs and their recent advances in set-up, data interpretation, and analytical applications. Journal of Pharmaceutical and Biomedical Analysis. ,vol. 56, pp. 141- 158 ,(2011) , 10.1016/J.JPBA.2011.04.023
Yong-hua Wang, Chen-feng Jing, Bo Yang, G. Mainda, Mei-ling Dong, An-long Xu, Production of a new sea anemone neurotoxin by recombinant Escherichia coli: Optimization of culture conditions using response surface methodology Process Biochemistry. ,vol. 40, pp. 2721- 2728 ,(2005) , 10.1016/J.PROCBIO.2004.12.024
Lawrence X. Yu, Gregory Amidon, Mansoor A. Khan, Stephen W. Hoag, James Polli, G. K. Raju, Janet Woodcock, Understanding Pharmaceutical Quality by Design The AAPS Journal. ,vol. 16, pp. 771- 783 ,(2014) , 10.1208/S12248-014-9598-3
Moritz von Stosch, Rui Oliveira, Joana Peres, Sebastião Feyo de Azevedo, Hybrid semi-parametric modeling in process systems engineering: Past, present and future Computers & Chemical Engineering. ,vol. 60, pp. 86- 101 ,(2014) , 10.1016/J.COMPCHEMENG.2013.08.008