How Malaria Parasites Acquire Nutrients From Their Host.

摘要: Plasmodium parasites responsible for the disease malaria reside within erythrocytes. Inside this niche host cell, internalize and digest hemoglobin to source amino acids required protein production. However, does not contain isoleucine, an acid essential growth, parasite cannot synthesize it de novo. The is also more metabolically active than its rate at which some nutrients are consumed exceeds they can be taken up by erythrocyte transporters. To overcome these constraints, increase permeability of membrane isoleucine other low-molecular-weight solutes requires growth forming new permeation pathways (NPPs). In addition membrane, need cross encasing parasitophorous vacuole (PVM) plasma access parasite. This review outlines recent advances that have been made in identifying molecular constituents NPPs, PVM nutrient channel, endocytic apparatus transports identifies key knowledge gaps remain. Importantly, blocking ability lethal parasite, thus, components represent potential antimalaria drug targets.