Topoisomerases and Apoptosis
作者： Olivier Sordet , Stéphanie Solier
DOI: 10.1007/978-1-4614-0323-4_19
关键词:
摘要: Topoisomerase inhibitors are among the most efficient inducers of apoptosis. They effectively produce DNA double-strand breaks that activate mitochondrial pathway to cell death, leading caspase activation and nuclear dismantling. Transmission signal from damage mitochondria involves cycle checkpoint repair proteins regulate Bcl-2 family promote membrane permeabilization death. Besides their role in initiation apoptosis, topoisomerases also participate directly modifications associated with We will review dual function as executors
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