Beta-receptor activation increases sodium current in guinea pig heart.
作者： Hong-wei Wang , Zhi-fang Yang , Yin Zhang , Jian-min Yang , Yuan-mou Liu
DOI: 10.1038/APS.2009.96
关键词:
摘要: To study the influence of β-receptor activation on sodium channel current and physiological significance increased with regard to cardiac output caused by sympathetic excitation. Multiple experimental approaches, including ECG, action potential recording conventional microelectrodes, whole-cell measurements, single-channel recordings, pumping-force were applied guinea pig hearts isolated ventricular myocytes. Isoprenaline was found dose-dependently shorten QRS waves, increase amplitude Vmax potentials, augment fast current, occurrence frequencies open time constants long-open burst modes channel. Increased levels membrane-permeable cAMP have similar effects. In presence a calcium blocker, TTX reversed pumping force produced isoprenaline. Beta-adrenergic modulation increases inward accelerates conduction velocity within ventricles changing modes, which might both be conducive synchronous contraction heart enhance its function.
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