Correlation of testicular sperm extraction with morphological, biophysical and endocrine profiles in men with azoospermia due to primary gonadal failure.

摘要: To identify the predictive factors for testicular sperm extraction (TESE) and to understand pathology associated with TESE, we carried out a prospective study in 40 consecutive men azoospermia due primary gonadal failure. The main outcome measure was retrieval of at least one spermatozoon. Endocrine biophysical profiles, histology, Johnsen score spermatids were used as predictors extraction. Spermatogenesis quantified score. A variable pattern spermatogenesis common, being present 20 (50%) patients. Visualisation on histology showed strong association TESE (P < 0.0001). Statistically significant differences detected plasma follicle stimulating hormone (FSH) volume between patients who had hypospermatogenesis Sertoli cell-only or maturation arrest. There no score, endocrine profiles groups successful failed TESE. However, statistically trend occurred changes histological [chi2 trend, P = 0.001; Pearson's coefficient (r) 0.6], 0.022; r 0.5), 0.01; 0.5) FSH concentrations 0.044; 0.4), albeit limited degree. Difference interpretation patterns different assessors observed. type occupation risk Variable tubules same individual may explain poor correlation pattern. Differences amount tissue histopathology, misinterpretation rather than failure quantify Testicular predicted considerable overlap values means that single can provide perfect discrimination