Stress in biology and medicine, role in aging.

摘要: In this review, we present a short description of the history stress in medical literature followed by recapitulation its mechanisms, from cellular to organismal level and role aging. The importance was first taken up as subject experimental medicine physiologists, starting Claude Bernard's concept stability "milieu interieur", altered stress, others, culminating recently elucidation mechanisms at molecular level. These studies showed that oxidative is one most important frequent form biological aggression. Its accumulation over time for burnout syndrome neuronal There however positive side it also, redox signaling plays an functional coordination activities. still be more completely evaluated, have account planning efficient protective therapeutic interventions.