Neuroimaging biomarkers for early drug development in schizophrenia.

作者: Jason R. Tregellas

DOI: 10.1016/J.BIOPSYCH.2013.08.025

关键词:

摘要: Given the relative inability of currently available antipsychotic treatments to adequately provide sustained recovery and improve quality life for patients with schizophrenia, new treatment strategies are urgently needed. One way therapeutic development process may be an increased use biomarkers in early clinical trials. Reliable that reflect aspects disease pathophysiology can used determine if potential engaging their desired biological targets. This review evaluates three neuroimaging biomarkers: hippocampal hyperactivity, gamma-band deficits, default network abnormalities. These deficits have been widely replicated illness, correlate measures positive symptoms, consistent models pathology, shown initial promise as response studies strategies. Two key features these a guiding rationale focus this review, not dependent upon patients' performance specific cognitive tasks they analogues animal greatly increasing appeal biomarkers. Using such those proposed here establish having intended effect humans facilitate schizophrenia.

参考文章(118)
Anke Brockhaus-Dumke, Ralf Mueller, Ulrich Faigle, Joachim Klosterkoetter, Sensory gating revisited: relation between brain oscillations and auditory evoked potentials in schizophrenia. Schizophrenia Research. ,vol. 99, pp. 238- 249 ,(2008) , 10.1016/J.SCHRES.2007.10.034
Jordan P. Hamm, Casey S. Gilmore, Natalie A.M. Picchetti, Scott R. Sponheim, Brett A. Clementz, Abnormalities of neuronal oscillations and temporal integration to low- and high-frequency auditory stimulation in schizophrenia. Biological Psychiatry. ,vol. 69, pp. 989- 996 ,(2011) , 10.1016/J.BIOPSYCH.2010.11.021
Martijn P van den Heuvel, René CW Mandl, Thomas Scheeuwe, Wiepke Kahn, René S Kahn, Hilleke E Hulshoff Pol, None, FUNCTIONAL CONNECTIVITY IN SCHIZOPHRENIA Schizophrenia Research. ,vol. 117, pp. 475- 475 ,(2010) , 10.1016/J.SCHRES.2010.02.894
Daphne J. Holt, Anthony P. Weiss, Scott L. Rauch, Christopher I. Wright, Martin Zalesak, Donald C. Goff, Tali Ditman, Robert C. Welsh, Stephan Heckers, Sustained activation of the hippocampus in response to fearful faces in schizophrenia. Biological Psychiatry. ,vol. 57, pp. 1011- 1019 ,(2005) , 10.1016/J.BIOPSYCH.2005.01.033
F. M. Benes, B. Lim, D. Matzilevich, J. P. Walsh, S. Subburaju, M. Minns, Regulation of the GABA cell phenotype in hippocampus of schizophrenics and bipolars Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 10164- 10169 ,(2007) , 10.1073/PNAS.0703806104
Gregor Leicht, Susanne Karch, Evangelos Karamatskos, Ina Giegling, Hans-Jürgen Möller, Ulrich Hegerl, Oliver Pogarell, Dan Rujescu, Christoph Mulert, Alterations of the early auditory evoked gamma-band response in first-degree relatives of patients with schizophrenia: hints to a new intermediate phenotype. Journal of Psychiatric Research. ,vol. 45, pp. 699- 705 ,(2011) , 10.1016/J.JPSYCHIRES.2010.10.002
S. Hirano, Y. Hirano, T. Maekawa, C. Obayashi, N. Oribe, T. Kuroki, S. Kanba, T. Onitsuka, Abnormal Neural Oscillatory Activity to Speech Sounds in Schizophrenia : A Magnetoencephalography Study The Journal of Neuroscience. ,vol. 28, pp. 4897- 4903 ,(2008) , 10.1523/JNEUROSCI.5031-07.2008
Dardo Tomasi, Nora D. Volkow, Ruiliang Wang, Frank Telang, Gene-Jack Wang, Linda Chang, Thomas Ernst, Joanna S. Fowler, Dopamine Transporters in Striatum Correlate with Deactivation in the Default Mode Network during Visuospatial Attention PLoS ONE. ,vol. 4, pp. e6102- ,(2009) , 10.1371/JOURNAL.PONE.0006102
K. M. Spencer, P. G. Nestor, R. Perlmutter, M. A. Niznikiewicz, M. C. Klump, M. Frumin, M. E. Shenton, R. W. McCarley, Neural synchrony indexes disordered perception and cognition in schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 17288- 17293 ,(2004) , 10.1073/PNAS.0406074101
Fabio Sambataro, Giuseppe Blasi, Leonardo Fazio, Grazia Caforio, Paolo Taurisano, Raffaella Romano, Annabella Di Giorgio, Barbara Gelao, Luciana Lo Bianco, Apostolos Papazacharias, Teresa Popolizio, Marcello Nardini, Alessandro Bertolino, Treatment with olanzapine is associated with modulation of the default mode network in patients with Schizophrenia. Neuropsychopharmacology. ,vol. 35, pp. 904- 912 ,(2010) , 10.1038/NPP.2009.192