Nano ZnO catalyzed green synthesis and cytotoxic assay of pyridinyl and pyrimidinyl bisphosphonates
作者： Gundluru Mohan , Sarva Santhisudha , Nadiveedhi Maheshwara Reddy , Tellamekala Sreekanth , Sudileti Murali
DOI: 10.1007/S00706-017-2000-2
关键词:
摘要: A straight forward approach ensuring the anchoring of bisphosphonate moiety onto various pyridinyl and pyrimidinyl amines is described by three-component reaction an amine, diethyl phosphite, triethyl orthoformate in presence catalytic amount nano ZnO as environmentally benign heterogeneous catalyst under solvent-free microwave irradiation conditions. All synthesized compounds are evaluated for anti-cell proliferation activity against human breast (MCF-7), prostate (DU-145), osteosarcoma (MG-63), fibrosarcoma (HT-1080), multiple myeloma (RPMI-8226) cancer cell lines using sulforhodamine-B (SRB) assay method, adriamycin a reference drug. title showed promising cytotoxic on five lines. One compound was two times more active than all
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