Cardiac abnormalities in acromegaly. Pathophysiology and implications for management.

摘要: Cardiovascular disease is claimed to be one of the most severe complications acromegaly, contributing significantly mortality in this disease. In fact, an excess growth hormone (GH) and insulin-like factor 1 (IGF-I) causes a specific derangement cardiomyocytes, leading abnormalities cardiac muscle structure function, inducing cardiomyopathy. early phase acromegaly GH IGF-I induces hyperkinetic syndrome, characterized by increased heart rate systolic output. Concentric hypertrophy common feature involvement found more than two thirds patients at diagnosis. This abnormality commonly associated with diastolic dysfunction eventually impaired function ending failure, if GH/IGF-I left untreated. addition, rhythm valves have also been described acromegaly. The coexistence other complications, such as arterial hypertension diabetes mellitus, aggravates acromegalic Successful control decrease ventricular mass improvement while effects suppression on are variable. However, since cardiovascular alterations young short duration milder those longer duration, it likely easier reverse and/or arrest cardiomyopathy early-onset conclusion, careful assessments morphology, activity required An diagnosis prompt effective treatment important order