Long-term Outcomes and Toxicity in Patients Treated With Brachytherapy for Prostate Adenocarcinoma Younger Than 60 Years of Age at Treatment With Minimum 10 Years of Follow-up

摘要: Objective To report the outcomes and late toxicities in younger patients with long-term follow-up treated brachytherapy or without external beam radiotherapy for prostate adenocarcinoma. Materials Methods Patients who were aged ≤60 years at treatment with ≥10 of selected from our database. The analyzed regarding biochemical failure, distant metastases, cause death. Genitourinary assessed using International Prostate Symptom Score, Radiation Therapy Oncology Group, Common Terminology Criteria Adverse Events criteria. Gastrointestinal toxicity was measured Group scales. Erectile dysfunction Sexual Health Inventory Men Mount Sinai Function score. Results A total 131 met inclusion criteria, a median age 57 11.5 years. Of this cohort, 9.9% developed failure 1 cancer-related death after 10 Score statistically unchanged 22 cases (17%) grade 2 greater genitourinary toxicities, only 6 (4.5%) continued 11 (8.3%) gastrointestinal events, none persisted past significant decrease occurred mean score 19.5 to 15.3 (P = .008). potent before treatment, 69% remained last follow-up. 4 second malignancies detected, which within radiation field. Conclusion