The role of formulation on the pharmacokinetics of antiretroviral drugs.
作者： Diane ET Bastiaans , Tim R Cressey , Herman Vromans , David M Burger
DOI: 10.1517/17425255.2014.925879
关键词:
摘要: Introduction: A multitude of antiretroviral drug formulations are now available for HIV-infected adults and children. These include individual co-formulated drugs, many which also supplied in generic versions. Many drugs have a low aqueous solubility poor bioavailability. Drug formulation can significantly affect bioavailability, given the increasing number new combinations, it is important to be aware that influence pharmacokinetics drugs.Areas covered: This review provides an overview studies assessing different children, including fixed-dose combinations. For some differences been described, with largest exposure when liquid compared tablet or capsule formulation. Biopharmaceutical properties relevant bioavailabi...
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