Conserved MIP receptor–ligand pair regulates Platynereis larval settlement

摘要: Life-cycle transitions connecting larval and juvenile stages in metazoans are orchestrated by neuroendocrine signals including neuropeptides hormones. In marine invertebrate life cycles, which often consist of planktonic benthic adult stages, settlement the free-swimming larva to sea floor response environmental cues is a key cycle transition. Settlement regulated specialized sensory–neurosecretory system, apical organ. The mechanisms through organ transduces into behavioral responses during not yet understood. Here we show that myoinhibitory peptide (MIP)/allatostatin-B, pleiotropic neuropeptide widespread among protostomes, regulates annelid Platynereis dumerilii. MIP expressed chemosensory–neurosecretory cells its receptor, an orthologue Drosophila sex neighboring cells. We demonstrate morpholino-mediated knockdown via this receptor trigger settlement. These results reveal role for conserved receptor–ligand pair regulating