Transcriptional control by E2F.

摘要: Abstract Considerable evidence suggests that the E2F/DRTF1 family of transcription factors (hereafter referred to as ‘E2F’) plays a critical role in cell growth control. For example, ability several small DNA tumour viruses, such SV40, adenovirus and human papillomavirus, transform certain cells is tightly linked their deregulate E2F. Furthermore, E2F appears directly regulate diverse set genes implicated replication Finally, number known cycle regulators, some which are commonly mutated tumours, appear exert effects, at least part, by altering activity. Among these pRb, p53, cdk-2, cdk-4 cyclins.