Aptamer-Mediated siRNA Targeting
作者： Jiehua Zhou , John J. Rossi
DOI: 10.1007/978-1-4614-4744-3_10
关键词:
摘要: RNA interference (RNAi) is a sequence-specific mechanism for posttranscriptional inhibition of gene expression. As such, it an attractive approach the therapeutic treatment wide variety human maladies. Although conceptually elegant, there are key barriers to widespread clinical application this process. One most formidable impediments translation RNAi safe and effective delivery siRNAs desired target tissue at doses. In regard, advent versatile aptamer technology has prompted development aptamer-mediated cell-type-specific targeted triggers. chapter, we explore developments applications. We also highlight recent advances aptamers as functionalized nanocarriers siRNA delivery.
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