Coping with physiological oxidative stress: a review of antioxidant strategies in seals

摘要: While diving, seals are exposed to apnea-induced hypoxemia and repetitive cycles of ischemia/reperfusion. on land, experience sleep apnea, as well prolonged periods food water deprivation. Prolonged fasting, ischemia/reperfusion increase oxidant production oxidative stress in terrestrial mammals. In seals, however, neither fasting nor or systemic local damage. The strategies evolved cope with increased reviewed the present manuscript. Among these strategies, high antioxidant capacity oxidant-mediated activation hormetic responses against hypoxia discussed. addition expanding our knowledge evolution defenses adaptive stress, understanding mechanisms that naturally allow mammals avoid damage has potential advance stress-induced pathologies enhance translative value biomedical therapies long term.