Ex vivo T-cell depletion with the monoclonal antibody Campath-1 plus human complement effectively prevents acute graft-versus-host disease in allogeneic bone marrow transplantation.
作者： W. Heit , D. Bunjes , M. Wiesneth , T. Schmeiser , R. Arnold
DOI: 10.1111/J.1365-2141.1986.TB02203.X
关键词:
摘要: Summary. We have developed a rapid and simple procedure for the elimination of mature T-cells from donor marrow using single incubation with monoclonal antibody Campath-1 complement. This resulted in reduction T-cell contamination to mean 1%. regimen reduced incidence acute graft-versus-host disease significantly 21 consecutive bone grafts 18 patients leukaemia non-Hodgkin's lymphoma. Purging was responsible an increased graft rejection HLA-identical transplants (13%).
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