Ghrelin as a prominent endocrine factor in stress-induced obesity.
作者： Mark R. van Loenen , Bram Geenen , Ilse A. C. Arnoldussen , Amanda J. Kiliaan
DOI: 10.1080/1028415X.2020.1863740
关键词:
摘要: Objectives: Ghrelin acts on a variety of central- and peripheral organs causing an orexigenic effect, conclusively followed by increased caloric intake. Recent studies have indicated that ghrelin's function as agent does not entirely reflect the full functional properties peptide. Specifically, ghrelin regulates stress-hormone synthesis secretion therewith affecting stress-axis. The role stress in development obesity has been extensively studied. However, underlying stress-regulatory effect yet further considered stress-induced obesity. Methods: Therefore, this review aims to accentuate potential factor pathological Results: In we discuss (1) ghrelin-mediated intracellular cascades elucidate overall bioactivation peptide, (2) mechanisms signalling regulation within central nervous system gastro-intestinal system. Discussion: These biological processes will be ultimately discussed relation pathogenesis
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