Protection of rhesus macaques against vaginal SHIV challenges by VRC01 and an anti-α4β7 antibody
作者： Giulia Calenda , Ines Frank , Géraldine Arrode-Brusés , Amarendra Pegu , Keyun Wang
DOI: 10.1101/365551
关键词:
摘要: Passive transfer of VRC01 protects macaques from vaginal SHIV infection after a single high-dose challenge. Protection against repeated rectal challenges decreases with decreased antibody levels weeks infusion. has not been tested; however, it is expected to decrease similarly. Infusion simianized anti-α4β7 mAb (Rh-α4β7) just prior to, and during exposures SIVmac251 partially protected SIV minimized the decline CD4+ T cells. To investigate impact combining Rh-α4β7 on infection, 3 groups were treated suboptimal dosing alone or in combination control antibodies initiation weekly high dose (1000TCID50) SHIVAD8-EO. The Rh-α4β7-VRC01 significantly delayed SHIVAD8-EO infection. Following VRC01-Rh-α4β7-treated maintained higher cell counts compared other exhibited lower SIV-DNA loads controls. Interestingly, had less IL-17 producing cells blood gut tissue acute phase responses V2-loop envelope groups. amounts altered anti-viral immune loss. Further exploration effect bNAbs SIV/HIV warranted may lead novel preventive therapeutic strategies.
sci-hub.st 参考文章(50)
Yoshiaki Nishimura, Rajeev Gautam, Tae-Wook Chun, Reza Sadjadpour, Kathryn E. Foulds, Masashi Shingai, Florian Klein, Anna Gazumyan, Jovana Golijanin, Mitzi Donaldson, Olivia K. Donau, Ronald J. Plishka, Alicia Buckler-White, Michael S. Seaman, Jeffrey D. Lifson, Richard A. Koup, Anthony S. Fauci, Michel C. Nussenzweig, Malcolm A. Martin, Early antibody therapy can induce long-lasting immunity to SHIV Nature. ,vol. 543, pp. 559- 563 ,(2017) , 10.1038/NATURE21435
Deborah J. Anderson, Joseph A. Politch, Larry Zeitlin, Andy Hiatt, Kadryn Kadasia, Kenneth H. Mayer, Ruth M. Ruprecht, Francois Villinger, Kevin J. Whaley, Systemic and topical use of monoclonal antibodies to prevent the sexual transmission of HIV. AIDS. ,vol. 31, pp. 1505- 1517 ,(2017) , 10.1097/QAD.0000000000001521
Yoshiaki Nishimura, Malcolm A. Martin, Of Mice, Macaques, and Men: Broadly Neutralizing Antibody Immunotherapy for HIV-1 Cell Host & Microbe. ,vol. 22, pp. 207- 216 ,(2017) , 10.1016/J.CHOM.2017.07.010
Ling Xu, Amarendra Pegu, Ercole Rao, Nicole Doria-Rose, Jochen Beninga, Krisha McKee, Dana M. Lord, Ronnie R. Wei, Gejing Deng, Mark Louder, Stephen D. Schmidt, Zachary Mankoff, Lan Wu, Mangaiarkarasi Asokan, Christian Beil, Christian Lange, Wulf Dirk Leuschner, Jochen Kruip, Rebecca Sendak, Young Do Kwon, Tongqing Zhou, Xuejun Chen, Robert T. Bailer, Keyun Wang, Misook Choe, Lawrence J. Tartaglia, Dan H. Barouch, Sijy O’Dell, John-Paul Todd, Dennis R. Burton, Mario Roederer, Mark Connors, Richard A. Koup, Peter D. Kwong, Zhi-yong Yang, John R. Mascola, Gary J. Nabel, Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques Science. ,vol. 358, pp. 85- 90 ,(2017) , 10.1126/SCIENCE.AAN8630
Lynn Morris, Nonhlanhla N. Mkhize, Prospects for passive immunity to prevent HIV infection. PLOS Medicine. ,vol. 14, ,(2017) , 10.1371/JOURNAL.PMED.1002436
Casey K. Hua, Margaret E. Ackerman, Increasing the Clinical Potential and Applications of Anti-HIV Antibodies. Frontiers in Immunology. ,vol. 8, pp. 1655- 1655 ,(2017) , 10.3389/FIMMU.2017.01655
Giulia Calenda, Rassamon Keawvichit, Géraldine Arrode-Brusés, Kovit Pattanapanyasat, Ines Frank, Siddappa N. Byrareddy, James Arthos, Claudia Cicala, Brooke Grasperge, James L. Blanchard, Agegnehu Gettie, Keith A. Reimann, Aftab A. Ansari, Elena Martinelli, Integrin α4β7 Blockade Preferentially Impacts CCR6+ Lymphocyte Subsets in Blood and Mucosal Tissues of Naive Rhesus Macaques. Journal of Immunology. ,vol. 200, pp. 810- 820 ,(2018) , 10.4049/JIMMUNOL.1701150
P J Santangelo, C Cicala, S N Byrareddy, K T Ortiz, D Little, K E Lindsay, S Gumber, J J Hong, K Jelicic, K A Rogers, C Zurla, F Villinger, A A Ansari, A S Fauci, J Arthos, Early treatment of SIV+ macaques with an α 4 β 7 mAb alters virus distribution and preserves CD4 + T cells in later stages of infection Mucosal Immunology. ,vol. 11, pp. 932- 946 ,(2018) , 10.1038/MI.2017.112
Aida Sivro, Alexandra Schuetz, Daniel Sheward, Vineet Joag, Sergey Yegorov, Lenine J. Liebenberg, Nonhlanhla Yende-Zuma, Andrew Stalker, Ruth S. Mwatelah, Philippe Selhorst, Nigel Garrett, Natasha Samsunder, Anisha Balgobin, Fatima Nawaz, Claudia Cicala, James Arthos, Anthony S. Fauci, Aggrey Omu Anzala, Joshua Kimani, Bernard S. Bagaya, Noah Kiwanuka, Carolyn Williamson, Rupert Kaul, Jo-Ann S. Passmore, Nittaya Phanuphak, Jintanat Ananworanich, Aftab Ansari, Quarraisha Abdool Karim, Salim S. Abdool Karim, Lyle R. McKinnon, , Integrin α4β7 expression on peripheral blood CD4+ T cells predicts HIV acquisition and disease progression outcomes Science Translational Medicine. ,vol. 10, ,(2018) , 10.1126/SCITRANSLMED.AAM6354
Kshitij Wagh, Michael S. Seaman, Marshall Zingg, Tomas Fitzsimons, Dan H. Barouch, Dennis R. Burton, Mark Connors, David D. Ho, John R. Mascola, Michel C. Nussenzweig, Jeffrey Ravetch, Rajeev Gautam, Malcolm A. Martin, David C. Montefiori, Bette Korber, Potential of conventional & bispecific broadly neutralizing antibodies for prevention of HIV-1 subtype A, C & D infections PLOS Pathogens. ,vol. 14, ,(2018) , 10.1371/JOURNAL.PPAT.1006860